Loss of protein quality is a driving force of aging. Misfolded proteins accumulate over time and represent a vulnerability for long-lived cells, such as blood stem cells. How these cells avert the effects of aging and maintain a high regenerative potential is poorly understood.
Our latest research has unveiled that the synthesis of intrinsically disordered proteins becomes a critical limiting factor as organisms age. However, blood-forming stem cells circumvent this challenge by producing elevated levels of the chaperone Cyclophilin A.
For a more detailed exploration of our findings, you can access the manuscript through the provided link. Additionally, below is a brief video abstract (7 minutes long) that gives an overview of our work.
Catic Lab 